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- Title
Neonatal abstinence syndrome is a potential cause of low TREC copy number.
- Authors
Adatia, Adil; Ling, Ling; Chakraborty, Pranesh; Brick, Lauren; Brager, Rae
- Abstract
Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number.
- Subjects
NEONATAL abstinence syndrome; SEVERE combined immunodeficiency; T cell receptors; T cells; CELL physiology
- Publication
Allergy, Asthma & Clinical Immunology, 2021, Vol 17, Issue 1, p1
- ISSN
1710-1484
- Publication type
Letter
- DOI
10.1186/s13223-021-00617-3