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- Title
Polyelectrolytes Formulated with Primary Unconjugated Bile Acid Optimised Pharmacology of Bio-Engineered Implant.
- Authors
Mooranian, Armin; Ionescu, Corina Mihaela; Wagle, Susbin Raj; Kovacevic, Bozica; Walker, Daniel; Jones, Melissa; Chester, Jacqueline; Foster, Thomas; Johnston, Edan; Kojic, Sanja; Stojanovic, Goran; Mikov, Momir; Al-Salami, Hani
- Abstract
Introduction. Several studies have shown that different biomaterials and hydrogels comprising various bile acids such as chenodeoxycholic acid (CDCA), as well as excipients such as poly-(styrene)-sulphonate (PSS) and poly-(allyl)-amine (PAA), exhibited positive biological effects on encapsulated viable pancreatic β-cells. Hence, this study aimed to investigate whether incorporating CDCA with PSS and PAA will optimise the functions of encapsulated pancreatic islets post-transplantation in Type 1 diabetes (T1D). Methods. Mice were made T1D, divided into two equal groups, and transplanted with encapsulated islets in PSS-PAA (control) or with CDCA-PSS-PAA (treatment) microcapsules. The effects of transplanted microcapsules on blood glucose, inflammation and the bile acid profile were measured post-transplantation. Results and Conclusion. Compared with control, the treatment group showed better survival rate, improved glycaemic control, and lower inflammatory profile, illustrated by ↓ interleukin 1-β, interleukin-6, interleukin-12, and tumour-necrosis factor-α, and ↓ levels of the bile acid, as well as lithocholic acid in the plasma, liver, large intestine and faeces. The results suggest that CDCA incorporation with PSS-PAA microcapsules exerted beneficial effects on encapsulated islets and resulted in enhanced diabetes treatment, post-transplantation, at the local and systemic levels.
- Subjects
BILE acids; ENTEROHEPATIC circulation; GLYCEMIC control; POLYELECTROLYTES; TYPE 1 diabetes; SURVIVAL rate
- Publication
Pharmaceutics, 2021, Vol 13, Issue 10, p1713
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics13101713