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- Title
MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy.
- Authors
Patterson, Erin E.; Holloway, Alisha K.; Weng, Julie; Fojo, Tito; Kebebew, Electron
- Abstract
The article discusses research on molecular markers that can aid in the diagnosis of adrenocortical carcinoma. Microarray profiling of adrenocortical tumors was conducted to identify differentially expressed microRNAs (MiRNAs or miRs) and was validated through quantitative real-time Reverse-Transcription Polymerase Chain Reaction. Results revealed significantly down-regulated miRs-100, -125b, and -195, and significantly up-regulated miR-483-5p in malignant tumors compared with benign tumors.
- Subjects
TUMOR diagnosis; POLYMERASE chain reaction; ADRENAL cortex; CANCER-related mortality; METASTASIS; MORPHOLOGY
- Publication
Cancer (0008543X), 2011, Vol 117, Issue 8, p1630
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.25724