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- Title
Correlation between PPAR Gene Polymorphisms and Primary Nephrotic Syndrome in Children.
- Authors
Jiaping Jin; Guixia Ding; Huaying Bao; Ying Chen; Yuan Han; Fei Zhao; Songming Huang; Aihua Zhang
- Abstract
Pediatric primary nephrotic syndrome (PNS) is a chronic disease promoted by metabolic and immune dysfunctions. Peroxisome proliferator-activated receptor (PPAR) polymorphisms have been associated with a variety of metabolic and kidney disorders. We therefore hypothesized that PPAR polymorphisms might be involved in the pathophysiology of PNS. We compared the distributions of the PPAR-γ Pro12Ala and Val290Met, PPAR-γ coactivator-α (PGC-1α) Gly482Ser, and PPAR-α Leu162Val single nucleotide polymorphisms (SNPs) between children with PNS and normal controls and analyzed their correlations with clinical and metabolic indicators and steroid responsiveness. There were no significant differences in distributions of any of the polymorphisms between PNS cases and controls. However, PNS patients with the PPAR-γ (Pro12Ala) PP genotype had significantly higher fasting serum insulin, IgA, and HOMA-IR levels and lower insulin sensitivity than did patients with PA and AA genotypes. Additionally, the PGC-1α (Gly482Ser) A allele was associated with lower CD8+ T-cell counts and higher triglyceride and complement C3 levels compared with the G allele. No polymorphisms were related to hormone sensitivity. These results suggest that the PPAR-γ (Pro12Ala) and PGC-1α (Gly482Ser) SNPs may influence insulin and triglyceride metabolism in children with PNS and may thus be relevant to the prognosis of this chronic condition.
- Subjects
NEPHROTIC syndrome treatment; PEROXISOME proliferator-activated receptors; NEPHROTIC syndrome in children; TRIGLYCERIDES; SINGLE nucleotide polymorphisms
- Publication
PPAR Research, 2013, p1
- ISSN
1687-4757
- Publication type
Article
- DOI
10.1155/2013/927915