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- Title
Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study.
- Authors
Fransson, Eleonor I; Batty, G David; Tabák, Adam G; Brunner, Eric J; Kumari, Meena; Shipley, Martin J; Singh-Manoux, Archana; Kivimäki, Mika
- Abstract
<bold>Context: </bold>Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown.<bold>Objective: </bold>The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status.<bold>Design and Setting: </bold>The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991-1993 and 2002-2004 (mean follow-up, 11.3 yr).<bold>Participants: </bold>We studied 2496 men and 1026 women [mean age, 49.4 (sd=6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up.<bold>Main Outcome Measures: </bold>We measured change in serum CRP and IL-6 during follow-up.<bold>Results: </bold>The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07-0.09] mg/liter and 0.04 (95% CI, 0.03-0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05-0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2) was greater: 0.08 (95% CI, 0.06-0.09) mg/liter and 0.11 (95% CI, 0.07-0.14) mg/liter, respectively (P value for interaction=0.002). Similar patterns were observed for changes in BMI and waist circumference.<bold>Conclusions: </bold>Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight.
- Subjects
OBESITY complications; BODY composition; BODY weight; C-reactive protein; COMPARATIVE studies; INFLAMMATION; INTERLEUKINS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; OBESITY; RESEARCH; RESEARCH funding; STATURE; WEIGHT gain; EVALUATION research; BODY mass index; WAIST circumference
- Publication
Journal of Clinical Endocrinology & Metabolism, 2010, Vol 95, Issue 12, p5370
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2010-0730