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- Title
Pancreatic hyperamylasemia during acute gastroenteritis: incidence and clinical relevance.
- Authors
Tositti, Giulia; Fabris, Paolo; Barnes, Eleonor; Furlan, Francesca; Franzetti, Marzia; Stecca, Clara; Pignattari, Elena; Pesavento, Valeria; De Lalla, Fausto; Tositti, G; Fabris, P; Barnes, E; Furlan, F; Franzetti, M; Stecca, C; Pignattari, E; Pesavento, V; de Lalla, F
- Abstract
<bold>Background: </bold>Many case reports of acute pancreatitis have been reported but, up to now, pancreatic abnormalities during acute gastroenteritis have not been studied prospectively.<bold>Objectives: </bold>To evaluate the incidence and the clinical significance of hyperamylasemia in 507 consecutive adult patients with acute gastroenteritis.<bold>Methods: </bold>The clinical significance of hyperamylasemia, related predisposing factors and severity of gastroenteritis were assessed.<bold>Results: </bold>Hyperamylasemia was detected in 10.2 % of patients studied. Although amylasemia was found over four times the normal values in three cases, the clinical features of acute pancreatitis were recorded in only one case (0.1%). Hyperamylasemia was more likely (17%) where a microorganism could be identified in the stools (p < 0.01). Among patients with positive stool samples, Salmonella spp. and in particular S. enteritidis, was the microorganism most frequently associated with hyperamylasemia [17/84 (20.2 %) and 10/45 (22.2%), respectively], followed by Rotavirus, Clostridium difficile and Campylobacter spp. Patients with hyperamylasemia had more severe gastroenteritis with an increased incidence of fever (80 % vs 50.6 %, O.R. 3.0; P < 0.01), dehydration (18% vs 8.5%; O.R. 2.5; P < 0.05), and a higher mean number of evacuations per day (9.2 vs 7.5; P < 0.05) than those with amylasemia in the normal range. Hyperamylasemia was significantly associated with cholelithiasis, (30.0 % vs 10.7%, O.R. 3.5; P < 0.01) and chronic gastritis or duodenal ulceration (22.0 % vs 10.2%, O.R. 2.4, P < 0.05).<bold>Conclusions: </bold>Hyperamylasemia is relatively frequent, and is associated with severe gastroenteritis. However, acute pancreatitis in the setting of acute gastroenteritis, is a rare event.
- Subjects
PANCREATIC diseases; GASTROENTERITIS; DISABILITIES; SALMONELLA enteritidis; SALMONELLA
- Publication
BMC Infectious Diseases, 2001, Vol 1, Issue 1, p18
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/1471-2334-1-18