We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Underwater versus conventional endoscopic mucosal resection for small size non-pedunculated colorectal polyps: a randomized controlled trial : (UEMR vs. CEMR for small size non-pedunculated colorectal polyps).
- Authors
Zhang, Zhixin; Xia, Yonghong; Cui, Hongyao; Yuan, Xin; Wang, Chunnian; Xie, Jiarong; Tong, Yarong; Wang, Weihong; Xu, Lei
- Abstract
<bold>Background: </bold>Underwater endoscopic mucosal resection (UEMR) is a recently developed technique and can be performed during water-aided or ordinary colonoscopy for the treatment of colorectal polyps. The objective of this clinical trial was to evaluate the efficacy and safety of UEMR in comparison with conventional endoscopic mucosal resection (CEMR) of small non-pedunculated colorectal polyps.<bold>Methods: </bold>Patients with small size, non-pedunculated colorectal polyps (4-9 mm in size) who underwent colonoscopic polypectomy were enrolled in this multicenter randomized controlled clinical trial. The patients were randomly allocated to two groups, an UEMR group and a CEMR group. Efficacy and safety were compared between groups.<bold>Results: </bold>In the intention-to-treat (ITT) analysis, the complete resection rate was 83.1% (59/71) in the UEMR group and 87.3% (62/71) in the CEMR group. The en-bloc resection rate was 94.4% (67/71) in the UEMR group and 91.5% (65/71) in the CEMR group (difference 2.9%; 90% CI - 4.2 to 9.9%), showed noninferiority (noninferiority margin - 5.7% < - 4.2%). No significant difference in procedure time (81 s vs. 72 s, P = 0.183) was observed. Early bleeding was observed in 1.4% of patients in the CEMR group (1/71) and 1.4% of patients in the UEMR group (1/71). None of the patients in the UEMR group complained of postprocedural bloody stool, whereas two patients in the CEMR group (2/64) reported this adverse event.<bold>Conclusion: </bold>Our results indicate that UEMR is safer and just as effective as CEMR in En-bloc resection for the treatment of small colorectal polyps as such, UEMR is recommended as an alternative approach to excising small and non-pedunculated colorectal adenomatous polyps.<bold>Trial Registration: </bold>Clinical Trials.gov, NCT03833492 . Retrospectively registered on February 7, 2019.
- Subjects
POLYPECTOMY; ENDOSCOPIC surgery; COLON polyps; RANDOMIZED controlled trials; CLINICAL trials; RESEARCH; COLONOSCOPY; INTESTINAL polyps; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COLORECTAL cancer; COMPARATIVE studies; RESEARCH funding; INTESTINAL mucosa
- Publication
BMC Gastroenterology, 2020, Vol 20, Issue 1, pN.PAG
- ISSN
1471-230X
- Publication type
journal article
- DOI
10.1186/s12876-020-01457-y