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MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.
Published in:
2011
By:
- Weiguo Zou;
- Greenblatt, Matthew B.;
- Jae-Hyuck Shim;
- Kant, Shashi;
- Bo Zhai;
- Lotinun, Sutada;
- Brady, Nicholas;
- Zhang Hu, Dorothy;
- Gygi, Steven P.;
- Baron, Roland;
- Davis, Roger J.;
- Jones, Dallas;
- Glimcher, Laurie H.;
- Zou, Weiguo;
- Shim, Jae-Hyuck;
- Zhai, Bo;
- Hu, Dorothy Zhang
Publication type:
journal article
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.
Published in:
2010
By:
- Greenblatt, Matthew B.;
- Jae-Hyuck Shim;
- Weiguo Zou;
- Sitara, Despina;
- Schweitzer, Michelle;
- Hu, Dorothy;
- Lotinun, Sutada;
- Sano, Yasuyo;
- Baron, Roland;
- Jin Mo Park;
- Arthur, Simon;
- Min Xie;
- Schneider, Michael D.;
- Bo Zhai;
- Gygi, Steven;
- Davis, Roger;
- Glimcher, Laurie H.;
- Shim, Jae-Hyuck;
- Zou, Weiguo;
- Park, Jin Mo
Publication type:
journal article
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34694-8
By:
- Lin, Chujiao;
- Yang, Qiyuan;
- Guo, Dongsheng;
- Xie, Jun;
- Yang, Yeon-Suk;
- Chaugule, Sachin;
- DeSouza, Ngoc;
- Oh, Won-Taek;
- Li, Rui;
- Chen, Zhihao;
- John, Aijaz A.;
- Qiu, Qiang;
- Zhu, Lihua Julie;
- Greenblatt, Matthew B.;
- Ghosh, Sankar;
- Li, Shaoguang;
- Gao, Guangping;
- Haynes, Cole;
- Emerson, Charles P.;
- Shim, Jae-Hyuck
Publication type:
Article
Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33956-9
By:
- Yang, Yeon-Suk;
- Kim, Jung-Min;
- Xie, Jun;
- Chaugule, Sachin;
- Lin, Chujiao;
- Ma, Hong;
- Hsiao, Edward;
- Hong, Jaehyoung;
- Chun, Hyonho;
- Shore, Eileen M.;
- Kaplan, Frederick S.;
- Gao, Guangping;
- Shim, Jae-Hyuck
Publication type:
Article
Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33956-9
By:
- Yang, Yeon-Suk;
- Kim, Jung-Min;
- Xie, Jun;
- Chaugule, Sachin;
- Lin, Chujiao;
- Ma, Hong;
- Hsiao, Edward;
- Hong, Jaehyoung;
- Chun, Hyonho;
- Shore, Eileen M.;
- Kaplan, Frederick S.;
- Gao, Guangping;
- Shim, Jae-Hyuck
Publication type:
Article
Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells.
Published in:
2010
By:
- Shin, Min-Jung;
- Shim, Jae-Hyuck;
- Lee, Jae-Young;
- Chae, Wook-Jin;
- Lee, Heung-Kyu;
- Morio, Tomohiro;
- Park, Jun;
- Chang, Eun-Ju;
- Lee, Sang-Kyou;
- Park, Jun Han
Publication type:
journal article
Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10289, doi. 10.3390/ijms221910289
By:
- Chaugule, Sachin;
- Kim, Jung-Min;
- Yang, Yeon-Suk;
- Knobeloch, Klaus-Peter;
- He, Xi;
- Shim, Jae-Hyuck
Publication type:
Article
The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 8, p. 1803, doi. 10.3390/ijms20081803
By:
- Kim, Jung-Min;
- Yang, Yeon-Suk;
- Park, Kwang Hwan;
- Oh, Hwanhee;
- Greenblatt, Matthew B.;
- Shim, Jae-Hyuck
Publication type:
Article
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
Published in:
Journal of Clinical Investigation, 2013, v. 123, n. 9, p. 4010, doi. 10.1172/JCI69443
By:
- Jae-Hyuck Shim;
- Greenblatt, Matthew B.;
- Weiguo Zou;
- Zhiwei Huang;
- Wein, Marc N.;
- Brady, Nicholas;
- Hu, Dorothy;
- Charron, Jean;
- Brodkin, Heather R.;
- Petsko, Gregory A.;
- Zaller, Dennis;
- Bo Zhai;
- Gygi, Steven;
- Glimcher, Laurie H.;
- Jones, Dallas C.
Publication type:
Article
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.
Published in:
2012
By:
- Shim JH;
- Greenblatt MB;
- Singh A;
- Brady N;
- Hu D;
- Drapp R;
- Ogawa W;
- Kasuga M;
- Noda T;
- Yang SH;
- Lee SK;
- Rebel VI;
- Glimcher LH;
- Shim, Jae-Hyuck;
- Greenblatt, Matthew B;
- Singh, Anju;
- Brady, Nicholas;
- Hu, Dorothy;
- Drapp, Rebecca;
- Ogawa, Wataru
Publication type:
journal article
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome--like skeletal defects induced by Pdk1 or Cbp mutations in mice.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 1, p. 91, doi. 10.1172/JCI59466
By:
- Jae-Hyuck Shim;
- Greenblatt, Matthew B.;
- Singh, Anju;
- Brady, Nicholas;
- Hu, Dorothy;
- Drapp, Rebecca;
- Ogawa, Wataru;
- Kasuga, Masato;
- Noda, Tetsuo;
- Sang-Hwa Yang;
- Sang-Kyou Lee;
- Rebel, Vivienne I.;
- Glimcher, Laurie H.
Publication type:
Article
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24819-w
By:
- Sun, Jun;
- Shin, Dong Yeon;
- Eiseman, Mark;
- Yallowitz, Alisha R.;
- Li, Na;
- Lalani, Sarfaraz;
- Li, Zan;
- Cung, Michelle;
- Bok, Seoyeon;
- Debnath, Shawon;
- Marquez, Sofia Jenia;
- White, Tommy E.;
- Khan, Abdul G.;
- Lorenz, Ivo C.;
- Shim, Jae-Hyuck;
- Lee, Francis S.;
- Xu, Ren;
- Greenblatt, Matthew B.
Publication type:
Article
TAK1 mediates BMP signaling in cartilage.
Published in:
Annals of the New York Academy of Sciences, 2010, v. 1192, n. 1, p. 385, doi. 10.1111/j.1749-6632.2009.05222.x
By:
- Greenblatt, Matthew B.;
- Shim, Jae‐Hyuck;
- Glimcher, Laurie H.
Publication type:
Article
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
Published in:
Journal of Cell Biology, 2006, v. 172, n. 7, p. 1045, doi. 10.1083/jcb.200509041
By:
- Shim, Jae-Hyuck;
- Xiao, Changchun;
- Hayden, Matthew S.;
- Lee, Ki-Young;
- Ghosh, Sankar;
- Trombetta, E. Sergio;
- Pypaert, Marc;
- Mellman, Ira;
- Nara, Atsuki;
- Yoshimori, Tamotsu;
- Wilm, Bettina;
- Hogan, Brigid L. M.;
- Erdjument-Bromage, Hediye;
- Tempst, Paul
Publication type:
Article
Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway.
Published in:
eLife, 2022, p. 1, doi. 10.7554/eLife.78069
By:
- Jung-Min Kim;
- Yeon-Suk Yang;
- Jaehyoung Hong;
- Chaugule, Sachin;
- Hyonho Chun;
- van der Meulen, Marjolein C. H.;
- Ren Xu;
- Greenblatt, Matthew B.;
- Shim, Jae-hyuck
Publication type:
Article
AAV-Mediated Targeting of the Activin A-ACVR1 R206H Signaling in Fibrodysplasia Ossificans Progressiva.
Published in:
Biomolecules (2218-273X), 2023, v. 13, n. 9, p. 1364, doi. 10.3390/biom13091364
By:
- Yang, Yeon-Suk;
- Lin, Chujiao;
- Ma, Hong;
- Xie, Jun;
- Kaplan, Frederick S.;
- Gao, Guangping;
- Shim, Jae-Hyuck
Publication type:
Article
CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.
Published in:
Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.02203
By:
- Kim, Mi-Jeong;
- Min, Yoon;
- Shim, Jae-Hyuck;
- Chun, Eunyoung;
- Lee, Ki-Young
Publication type:
Article
Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10809-6
By:
- Yang, Yeon-Suk;
- Xie, Jun;
- Wang, Dan;
- Kim, Jung-Min;
- Tai, Phillip W. L.;
- Gravallese, Ellen;
- Gao, Guangping;
- Shim, Jae-Hyuck
Publication type:
Article
TAK1 is an essential regulator of BMP signalling in cartilage.
Published in:
EMBO Journal, 2009, v. 28, n. 14, p. 2028, doi. 10.1038/emboj.2009.162
By:
- Jae-Hyuck Shim;
- Greenblatt, Matthew B.;
- Min Xie;
- Schneider, Michael D.;
- Weiguo Zou;
- Bo Zhai;
- Gygi, Steven;
- Glimcher, Laurie H.
Publication type:
Article
Cellular and Tissue Selectivity of AAV Serotypes for Gene Delivery to Chondrocytes and Cartilage.
Published in:
International Journal of Medical Sciences, 2021, v. 18, n. 15, p. 3353, doi. 10.7150/ijms.56760
By:
- Dong Suk Yoon;
- Kyoung-Mi Lee;
- Sehee Cho;
- Eun Ae Ko;
- Jihyun Kim;
- Sujin Jung;
- Jae-Hyuck Shim;
- Guangping Gao;
- Kwang Hwan Park;
- Jin Woo Lee
Publication type:
Article
The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid.
Published in:
Nature Cell Biology, 2011, v. 13, n. 1, p. 59, doi. 10.1038/ncb2134
By:
- Weiguo Zou;
- Xi Chen;
- Jae-Hyuck Shim;
- Zhiwei Huang;
- Brady, Nicholas;
- Hu, Dorothy;
- Drapp, Rebecca;
- Sigrist, Kirsten;
- Glimcher, Laurie H.;
- Jones, Dallas
Publication type:
Article
Sensors in Bone: Technologies, Applications, and Future Directions.
Published in:
Sensors (14248220), 2024, v. 24, n. 19, p. 6172, doi. 10.3390/s24196172
By:
- Anwar, Afreen;
- Kaur, Taruneet;
- Chaugule, Sachin;
- Yang, Yeon-Suk;
- Mago, Aryan;
- Shim, Jae-Hyuck;
- John, Aijaz Ahmad
Publication type:
Article
Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies.
Published in:
Sensors (14248220), 2023, v. 23, n. 18, p. 7904, doi. 10.3390/s23187904
By:
- Mago, Aryan;
- Yang, Yeon-Suk;
- Shim, Jae-Hyuck;
- John, Aijaz Ahmad
Publication type:
Article
T-bet represses T<sub>H</sub>17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt.
Published in:
Nature Immunology, 2011, v. 12, n. 1, p. 96, doi. 10.1038/ni.1969
By:
- Lazarevic, Vanja;
- Chen, Xi;
- Shim, Jae-Hyuck;
- Hwang, Eun-Sook;
- Jang, Eunjung;
- Bolm, Alexandra N;
- Oukka, Mohamed;
- Kuchroo, Vijay K;
- Glimcher, Laurie H
Publication type:
Article
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.
Published in:
Nature Communications, 2016, v. 7, n. 12, p. 13829, doi. 10.1038/ncomms13829
By:
- Poulos, Michael G.;
- Ramalingam, Pradeep;
- Gutkin, Michael C.;
- Kleppe, Maria;
- Ginsberg, Michael;
- Crowley, Michael J. P.;
- Elemento, Olivier;
- Levine, Ross L.;
- Rafii, Shahin;
- Kitajewski, Jan;
- Greenblatt, Matthew B.;
- Shim, Jae-Hyuck;
- Butler, Jason M.
Publication type:
Article
Osteoblast-Osteoclast Communication and Bone Homeostasis.
Published in:
Cells (2073-4409), 2020, v. 9, n. 9, p. 2073, doi. 10.3390/cells9092073
By:
- Kim, Jung-Min;
- Lin, Chujiao;
- Stavre, Zheni;
- Greenblatt, Matthew B.;
- Shim, Jae-Hyuck
Publication type:
Article
Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications.
Published in:
2018
By:
- Shim, Jae-hyuck;
- Stavre, Zheni;
- Gravallese, Ellen M.
Publication type:
journal article
c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo.
Published in:
Journal of Bone & Mineral Research, 2017, v. 32, n. 9, p. 1811, doi. 10.1002/jbmr.3184
By:
- Xu, Ren;
- Shin, Dong Yeon;
- Lalani, Sarfaraz;
- Li, Na;
- Liu, Yifang;
- Eiseman, Mark;
- Greenblatt, Matthew B;
- Zhang, Chao;
- Kim, Jung-Min;
- Yang, Yeon-Suk;
- Shim, Jae-Hyuck;
- Davis, Roger J
Publication type:
Article
Zinc inhibits osteoclast differentiation by suppression of Ca<sup>2+</sup>-Calcineurin-NFATc1 signaling pathway.
Published in:
Cell Communication & Signaling, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1478-811X-11-74
By:
- Kwang Hwan Park;
- Boryung Park;
- Dong Suk Yoon;
- Seung-Hyun Kwon;
- Dong Min Shin;
- Jin Woo Lee;
- Hyun Gyu Lee;
- Jae-Hyuck Shim;
- Jeon Han Park;
- Jae Myun Lee
Publication type:
Article
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19555-6
By:
- Bok, Seoyeon;
- Shin, Dong Yeon;
- Yallowitz, Alisha R.;
- Eiseman, Mark;
- Cung, Michelle;
- Xu, Ren;
- Li, Na;
- Sun, Jun;
- Williams, Alfred L.;
- Scott, John E.;
- Su, Bing;
- Shim, Jae-Hyuck;
- Greenblatt, Matthew B.
Publication type:
Article
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16038-6
By:
- Kim, Jung-Min;
- Yang, Yeon-Suk;
- Park, Kwang Hwan;
- Ge, Xianpeng;
- Xu, Ren;
- Li, Na;
- Song, Minkyung;
- Chun, Hyunho;
- Bok, Seoyeon;
- Charles, Julia F.;
- Filhol-Cochet, Odile;
- Boldyreff, Brigitte;
- Dinter, Teresa;
- Yu, Paul B.;
- Kon, Ning;
- Gu, Wei;
- Takarada, Takeshi;
- Greenblatt, Matthew B.;
- Shim, Jae-Hyuck
Publication type:
Article

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