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- Title
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection.
- Authors
Jones, Dallas; Glimcher, Laurie H.; Aliprantis, Antonios O.
- Abstract
Over the past decade and a half, the biomedical community has uncovered a previously unappreciated reciprocal relationship between cells of the immune and skeletal systems. Work in this field, which has been termed "osteoimmunology," has resulted in the development of clinical therapeutics for seemingly disparate diseases linked by the common themes of inflammation and bone remodeling. Here, the important concepts and discoveries in osteoimmunology are discussed in the context of the diseases bridging these two organ systems, including arthritis, osteoporosis, cancer, and infection, and the targeted treatments used by clinicians to combat them.
- Subjects
GAP junctions (Cell biology); TREATMENT of arthritis; INFECTION treatment; OSTEOPOROSIS treatment; CANCER treatment; BONE remodeling; IMMUNOLOGY; DRUG therapy for arthritis; ARTHRITIS; IMMUNE system; INFECTION; INTERLEUKINS; MACROPHAGES; MEMBRANE proteins; OSTEOPOROSIS; TUMORS; OSTEOBLASTS
- Publication
Journal of Clinical Investigation, 2011, Vol 121, Issue 7, p2534
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI46262