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- Title
Coagulopathy in Acute Puumala Hantavirus Infection.
- Authors
Koskela, Sirpa; Mäkelä, Satu; Strandin, Tomas; Vaheri, Antti; Outinen, Tuula; Joutsi-Korhonen, Lotta; Pörsti, Ilkka; Mustonen, Jukka; Laine, Outi
- Abstract
Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.
- Subjects
RUSSIA; HANTAVIRUS diseases; HEMORRHAGIC fever with renal syndrome; ACUTE kidney failure; DISSEMINATED intravascular coagulation; BLOOD coagulation disorders; AMNIOTIC fluid embolism; PLATELET count
- Publication
Viruses (1999-4915), 2021, Vol 13, Issue 8, p1553
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v13081553