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- Title
Stress Response and Translation Control in Rotavirus Infection.
- Authors
López, Susana; Oceguera, Alfonso; Sandoval-Jaime, Carlos
- Abstract
The general stress and innate immune responses are closely linked and overlap at many levels. The outcomes of these responses serve to reprogram host expression patterns to prevent viral invasions. In turn, viruses counter attack these cell responses to ensure their replication. The mechanisms by which viruses attempt to control host cell responses are as varied as the number of different virus families. One of the most recurrent strategies used by viruses to control the antiviral response of the cell is to hijack the translation machinery of the host, such that viral proteins are preferentially synthesized, while the expression of the stress and antiviral responses of the cell are blocked at the translation level. Here, we will review how rotaviruses, an important agent of acute severe gastroenteritis in children, overcome the stress responses of the cell to establish a productive infectious cycle.
- Subjects
ROTAVIRUS diseases; PHYSIOLOGICAL stress; IMMUNE response; VIRAL replication; ANTIVIRAL agents
- Publication
Viruses (1999-4915), 2016, Vol 8, Issue 6, p162
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v8060162