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- Title
Management and Neonatal Outcomes of Pregnancies with Fetal/Neonatal Alloimmune Thrombocytopenia: A Single-Center Retrospective Cohort Study.
- Authors
Ronzoni, Stefania; Keunen, Johannes; Shah, Prakeshkumar S.; Kelly, Edmond N.; Windrim, Rory; Seaward, P. Gareth; Ryan, Greg; Shah, Prakeshkumar S; Kelly, Edmond N; Seaward, P Gareth
- Abstract
<bold>Background: </bold>There is no consensus regarding the optimal antenatal treatment of fetal/neonatal alloimmune thrombocytopenia (F/NAIT). We aimed to review the fetal blood sampling (FBS)-related risk, fetal response to maternal intravenous immunoglobulin (IVIG), and cesarean section (CS) rate in pregnancies with a history of F/NAIT.<bold>Methods: </bold>Maternal demographics, alloantibodies, pregnancy management, fetal and neonatal outcomes, and index case characteristics were collected. Responders (R) and non-responders (NR) were defined as women treated with IVIG in whom fetal platelets (PLTs) were normal or low (< 50 × 109/L).<bold>Results: </bold>An FBS-related risk occurred in 1.6% (2/119) of procedures. Maternal characteristics did not differ between responders (n = 21) and non-responders (n = 21). HPA-1a antibody was detected in all non-responders and in 72% of responders (p < 0.01). The index case had a significantly lower PLT count at birth in non-responders versus responders (median PLT count: R = 20 × 109/L [IQR 8-43] vs. NR = 9 × 109/L [IQR 4-18], p < 0.02). No differences were found in IVIG treatment duration or dosage. PLTs at birth were significantly lower in non-responders compared to responders. No intracranial hemorrhages occurred. CSs were performed for obstetric indications only in all but two cases.<bold>Conclusion: </bold>Maternal IVIG can elicit different fetal responses. The lack of prognostic factors to predict responders or non-responders suggests that there remains a role for FBS in F/NAIT in experienced hands.
- Subjects
ALLOIMMUNITY; THROMBOCYTOPENIA; CORD blood; PRENATAL care; INTRAVENOUS immunoglobulins; BLOOD sampling
- Publication
Fetal Diagnosis & Therapy, 2019, Vol 45, Issue 2, p85
- ISSN
1015-3837
- Publication type
journal article
- DOI
10.1159/000487303