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- Title
Interaction of E1 and hSNF5 proteins stimulates replication of human papillomavirus DNA.
- Authors
Lee, Daeyoup; Sohn, Hekwang; Kalpana, Ganjam V.; Choe, Joonho
- Abstract
Presents research which identified the cellular factor that participates in viral DNA replication. DNA replication in mammalian viruses; Role of the human papillomavirus (HPV) E1 protein; Use of a two hybrid assay in Saccharomyces cerevisiae and E1 protein; Isolation and role of Ini1/hSNF5; Results of in vitro binding and immunoprecipitation of E1; Revelations from transient DNA-replication assay; Effects of amino-acid substitution at residues that are conserved among E1 proteins.
- Subjects
REGULATION of DNA replication; DNA viruses; PAPILLOMAVIRUS diseases; PROTEINS; PHYSIOLOGY; VIRAL replication; GENETICS
- Publication
Nature, 1999, Vol 399, Issue 6735, p487
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/20966