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- Title
Critical role of IL-15?IL-15R for antigen-presenting cell functions in the innate immune response.
- Authors
Ohteki, Toshiaki; Suzue, Kazutomo; Maki, Chikako; Ota, Takayuki; Koyasu, Shigeo
- Abstract
Activation of dendritic cells (DCs) and macrophages by infectious agents leads to secretion of interleukin 12 (IL-12), which subsequently induces interferon-γ (IFN-γ) production by multiple cell types that include DCs and macrophages. In turn, IFN-γ acts on macrophages to augment IL-12 secretion and to produce nitric oxide (NO), which eradicates infected microbes. We show here that in cytokine common γ subunit?deficient and/or IL-2 receptor β?deficient mice, production of IL-12, IFN-γ and NO by DCs and macrophages was severely impaired, as was up-regulation of major histocompatibility complex class II and CD40. Similar phenotypes were observed in DCs and macrophages from IL-15?deficient mice but not in those from IL-2?deficient mice. This shows that the IL-15?IL-15R interaction is critical in early activation of antigen-presenting cells and plays an important role in the innate immune system.
- Subjects
INTERLEUKINS; IMMUNE response
- Publication
Nature Immunology, 2001, Vol 2, Issue 12, p1138
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni729