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- Title
Effect of behavioral weight‐loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial.
- Authors
Collins, Katherine A.; Kraus, William E.; Rogers, Renee J.; Hauser, Elizabeth R.; Lang, Wei; Jiang, Rong; Schelbert, Erik B.; Huffman, Kim M.; Jakicic, John M.
- Abstract
Objective: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12‐month behavioral weight‐loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. Methods: Participants (N = 374) were randomized to either diet alone (DIET), diet plus 150 min/wk of prescribed moderate‐intensity physical activity (DIET + PA150), or diet plus 250 min/wk of prescribed moderate‐intensity physical activity (DIET + PA250). Biomarker concentrations were determined using nuclear magnetic resonance spectroscopy. Mixed models assessed for a time effect, group effect, or group by time interaction. Results: All groups significantly improved body weight (time: p < 0.0001), Lipoprotein Insulin Resistance Index score (time: p < 0.0001), Diabetes Risk Index score (time: p < 0.0001), branched‐chain amino acid concentration (time: p < 0.0001), and GlycA concentration (time: p < 0.0001), with no group effect or group by time interactions. Conclusions: All intervention groups prompted a notable beneficial change among biomarkers of insulin resistance and cardiometabolic health. However, the addition of at least moderate‐intensity physical activity to a diet‐only intervention did not provide any additional benefit. These findings highlight that an average weight loss of approximately 10% profoundly impacts biomarkers of insulin resistance and cardiometabolic disease in adults with overweight or obesity.
- Subjects
HEART metabolism disorders; NUCLEAR magnetic resonance spectroscopy; DISEASE risk factors; BIOMARKERS
- Publication
Obesity (19307381), 2023, Vol 31, Issue 2, p338
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1002/oby.23618