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- Title
Ossification and Bone Regeneration in a Canine GBR Model, Part 1: Thick vs Thin Glycated Cross-Linked Collagen Devices.
- Authors
Pesce, Paolo; Zubery, Yuval; Goldlust, Arie; Bayer, Thomas; Abundo, Roberto; Canullo, Luigi
- Abstract
Purpose: To compare glycated multilayered membranes (OV) to a commercially available thin-layer membrane (OP) in a lateral ridge augmentation model in dogs. Materials and Methods: This was designed as a three-arm study, where one negative control (empty defect) was compared to two test arms: alveolar bone defects grafted with a mixture of 90% deproteinized bovine bone mineral and 10% porcine collagen, then covered with either a thick- (OV) or thin-layered (OP) membrane. Animals were randomly divided into three groups corresponding to the final sacrifice times of 4 weeks, 12 weeks, and 24 weeks. Sections underwent microCT, histology, histopathology, and histomorphometry. Results: No statistical differences were observed for OV compared to OP regarding the percentage of mineral volume and mean mineral density, amount of bone maturation, percentage of bone graft and membrane remaining in the grafted area, alveolar ridge width measurements, membrane mineralization, or ossification. Test groups presented significantly higher values compared to the empty control for all the endpoints. Conclusions: Within its limitations, this in vivo study highlighted that multilayered thick glycated membranes can serve as effective occlusive barriers for up to 6 months.
- Subjects
METAPLASTIC ossification; COLLAGEN; CUSPIDS; BLOOD vessels; REGENERATION (Biology); REGRESSION analysis; SURGICAL technology; SURGICAL complications; ADVANCED glycation end-products; GLYCOPROTEINS; HISTOLOGY; COMPUTED tomography; ANIMALS
- Publication
International Journal of Oral & Maxillofacial Implants, 2023, Vol 38, Issue 4, p801
- ISSN
0882-2786
- Publication type
Article
- DOI
10.11607/jomi.9820