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- Title
Extended treatment for cigarette smoking cessation: a randomized control trial.
- Authors
Laude, Jennifer R.; Bailey, Steffani R.; Crew, Erin; Varady, Ann; Lembke, Anna; McFall, Danielle; Jeon, Anna; Killen, Diana; Killen, Joel D.; David, Sean P.
- Abstract
Aim To test the potential benefit of extending cognitive-behavioral therapy (CBT) relative to not extending CBT on long-term abstinence from smoking. Design Two-group parallel randomized controlled trial. Patients were randomized to receive non-extended CBT ( n = 111) or extended CBT ( n = 112) following a 26-week open-label treatment. Setting Community clinic in the United States. Participants A total of 219 smokers (mean age: 43 years; mean cigarettes/day: 18). Intervention All participants received 10 weeks of combined CBT + bupropion sustained release (bupropion SR) + nicotine patch and were continued on CBT and either no medications if abstinent, continued bupropion + nicotine replacement therapy (NRT) if increased craving or depression scores, or varenicline if still smoking at 10 weeks. Half the participants were randomized at 26 weeks to extended CBT (E-CBT) to week 48 and half to non-extended CBT (no additional CBT sessions). Measurements The primary outcome was expired CO-confirmed, 7-day point-prevalence (PP) at 52- and 104-week follow-up. Analyses were based on intention-to-treat. Findings PP abstinence rates at the 52-week follow-up were comparable across non-extended CBT (40%) and E-CBT (39%) groups [odds ratio (OR) = 0.99; 95% confidence interval (CI) = 0.55, 1.78]. A similar pattern was observed across non-extended CBT (39%) and E-CBT (33%) groups at the 104-week follow-up (OR = 0.79; 95% CI= 0.44, 1.40). Conclusion Prolonging cognitive-behavioral therapy from 26 to 48 weeks does not appear to improve long-term abstinence from smoking.
- Subjects
UNITED States; SMOKING cessation; TREATMENT effectiveness; BUPROPION; NICOTINE addiction treatment; NICOTINE replacement therapy; PSYCHOLOGY; EQUIPMENT &; supplies; THERAPEUTICS; COGNITIVE therapy; COMMUNITY health services; CONFIDENCE intervals; SMOKING; RANDOMIZED controlled trials; ODDS ratio
- Publication
Addiction, 2017, Vol 112, Issue 8, p1451
- ISSN
0965-2140
- Publication type
Article
- DOI
10.1111/add.13806