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- Title
The role of inflammation in cardiac arrhythmias pathophysiology.
- Authors
Budzianowski, Jan; Korybalska, Katarzyna; Bręborowicz, Andrzej
- Abstract
The pathophysiology of cardiac arrhythmias is highly complex. Infl ammation causes electrophysiological changes that contribute to increased vulnerability of arrhythmias, a process known as electrical remodeling. There have been many biomarkers and proteins associated with pathophysiology of cardiac arrhythmias such as C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-8, and monocyte chemoattractant protein-1. At present large attention is paid to the clinical studies on the infl ammation in the pathogenesis of the atrial fibrillation (AF), given the limited effectiveness of the current therapeutic approaches. Understanding the main process, molecular mechanism and signaling pathways underlying the pathogenesis of the infl ammatory dilated cardiomyopathy (iDCM) will be essential for developing new effective therapeutic strategies.
- Subjects
PATHOLOGICAL physiology; INFLAMMATION; ARRHYTHMIA treatment; TUMOR necrosis factors; ATRIAL fibrillation
- Publication
Journal of Medical Science, 2016, Vol 85, Issue 3, p197
- ISSN
2353-9798
- Publication type
Article
- DOI
10.20883/jms.2016.142