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- Title
Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1.
- Authors
Etemadi, Nima; Webb, Andrew; Bankovacki, Aleksandra; Silke, John; Nachbur, Ueli
- Abstract
Progranulin (proepithelin, granulin precursor) has been recently suggested to exhibit anti-inflammatory properties by directly binding to tumour necrosis factor (TNF) receptors and thereby inhibiting TNF signalling by Tang et al. This finding was challenged by Chen et al. and no interaction between progranulin and TNF receptor (TNFR) 1 or 2 was observed. We tested the ability of recombinant progranulin from different commercial sources to inhibit TNF- or lymphotoxin-α-induced signalling through TNFR1. We observed that progranulin does not affect signalling and cell death induction downstream of TNF or lymphotoxin-α. Our results suggest that the anti-inflammatory role of progranulin is not mediated through direct inhibition of TNFR1.
- Subjects
PROGRANULIN; ANTI-inflammatory agents; TUMOR necrosis factor receptors; RECOMBINANT proteins; CELL death; INHIBITION (Chemistry)
- Publication
Immunology & Cell Biology, 2013, Vol 91, Issue 10, p661
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1038/icb.2013.53