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- Title
Optimization of TCR transgenic T cells for in vivo tracking of immune responses.
- Authors
Stock, Angus T.; Mueller, Scott N.; Kleinert, Lauren M.; Heath, William R.; Carbone, Francis R.; Jones, Claerwen M.
- Abstract
T-cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen-experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus-specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T-cell transfer remains a useful means of tracking antiviral immune responses.Immunology and Cell Biology (2007) 85, 394–396; doi:10.1038/sj.icb.7100076; published online 5 June 2007
- Subjects
T-cell receptor genes; TRANSGENIC animals; CELL receptors; IMMUNE response; CYTOLOGY
- Publication
Immunology & Cell Biology, 2007, Vol 85, Issue 5, p394
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1038/sj.icb.7100076