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- Title
Extensive anal condylomatosis: prognosis in relation to viral and host factors.
- Authors
Sarzo, G.; Mistro, A.; Finco, C.; Frayle-Salamanca, H.; Marino, F.; Franzetti, M.; Ferrara, R.; Mistrangelo, M.; Savastano, S.; Vecchiato, M.; Merigliano, S.
- Abstract
Objective To evaluate the clinical course of extensive anal condylomatosis in relation to treatment modalities, patient comorbidity and immune function, and associated papillomavirus (HPV) sequences. Method Clinical data, treatment modalities and followup were recorded and analysed in relation to host and viral type. Histology, immunohistochemistry and molecular analyses for HPV search and typing were performed on formalin-fixed paraffin-embedded samples. Results Sixteen patients [14 males, median age 41.8 years (range 19-66)] affected by extensive anal condylomatosis [10 Buschke-Lowenstein Tumors (BLT) and 6 condylomatosis] treated in three different Italian institutions were included. There was associated preoperative anal intraepithelial neoplasia grade 3 (AIN3) in one and invasive carcinoma in three patients. After radical resection (n = 16) recurrence occurred in 4 / 10 (40%) BLT patients. Malignancy before or after treatment developed in 5 / 16 (31.25%) patients. HPV sequences were present in all the samples of 15 evaluable patients (types 6 or 11, 9 patients; type 16, 6 patients). A statistically significant association was found between presence of HPV type 16 and both malignancy and recurrence. Viral variant L83V was present in 3 / 4 HPV 16 positive recurrent cases. Conclusion Radical resection resulted in a favourable clinical course. Typing of HPV sequences in the management of patients affected by extensive anal condylomatosis may be useful.
- Subjects
PAPILLOMAVIRUSES; TUMORS; COMORBIDITY; IMMUNOHISTOCHEMISTRY; CARCINOMA
- Publication
Colorectal Disease, 2010, Vol 12, pe128
- ISSN
1462-8910
- Publication type
Article
- DOI
10.1111/j.1463-1318.2009.01902.x