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- Title
Effect of acute and long-term oral tobacco use on oesophageal motility<sup>1</sup>.
- Authors
Bhandarkar, Prashant V; Shah, Saumil K; Meshram, Megha; Abraham, Philip; Narayanan, Ts; Bhatia, Shobna J
- Abstract
AbstractBackground and Aims: Nicotine administration is known to decrease lower oesophageal sphincter (LOS) pressure. Although a few studies have assessed the effect of tobacco on the LOS, the effect of acute and long-term oral tobacco use on oesophageal motility is not known. The study was designed to investigate the effect of acute and long-term oral tobacco use on LOS and distal oesophageal motility. Methods: Thirty-six healthy men (aged 18–65 years, median 34 years; 18 oral tobacco users, 18 non-tobacco users) underwent oesophageal manometry using a water-perfusion system. After baseline manometry, tobacco users were asked to keep 0.5 g tobacco in their mouth for 10 min; non-users of tobacco were kept in quiet surroundings for a similar period. Manometry was then repeated. Results: The LOS basal pressures were similar in tobacco users and non-tobacco users (mean ± SD 15.4 ± 6.3 vs 13.4 ± 5.3 mmHg). In the distal oesophageal body, the velocity (4.4 ± 3.1 vs 4.9 ± 2.6 cm/s), amplitude (92.7 ± 38.3 vs 84.8 ± 33.2 mmHg) and duration of contraction (2.1 ± 0.7 vs 1.7 ± 0.9 s) were similar in tobacco users and non-users. Acute tobacco use did not affect these parameters. The numbers of abnormal waves (triple peaks and non-transmitted contractions) were also similar in the two groups. Conclusion: Oral tobacco use does not appear to affect LOS pressures and distal oesophageal motility acutely or in the long term.
- Subjects
SMOKELESS tobacco; ESOPHAGEAL motility; NICOTINE
- Publication
Journal of Gastroenterology & Hepatology, 2000, Vol 15, Issue 9, p1018
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1046/j.1440-1746.2000.02287.x