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- Title
Adsorptive Cathodic Stripping Voltammetric Determination of Cefoperazone in Bulk Powder, Pharmaceutical Dosage Forms, and Human Urine.
- Authors
Vu Dang Hoang; Dao Thi Huyen; Phan Hong Phuc
- Abstract
The electroreduction behaviour and determination of cefoperazone using a hanging mercury drop electrode were investigated. Cyclic voltammograms of cefoperazone recorded in universal Britton-Robinson buffers pH 3-6 exhibited a single irreversible cathodic peak. The process was adsorption-controlled. Britton-Robinson buffer 0.04M pH 4.0 was selected as a supporting electrolyte for quantitative purposes by differential pulse and square wave adsorptive cathodic stripping voltammetry. The experimental voltammetric conditions were optimized using Central Composite Face design. A reduction wave was seen in the range from -0.7 to -0.8V. These voltammetric techniques were successfully validated as per ICH guidelines and applied for the determination of cefoperazone in its single and sulbactam containing powders for injection and statistically comparable to USPHPLC. They were further extended to determine cefoperazone in spiked human urine with no matrix effect.
- Subjects
ELECTROLYTIC reduction; DOSAGE forms of drugs; URINALYSIS; MERCURY electrodes; CEFOPERAZONE; VOLTAMMETRY; ADSORPTIVE separation; PHARMACEUTICAL powders
- Publication
Journal of Analytical Methods in Chemistry, 2013, p1
- ISSN
2090-8865
- Publication type
Article
- DOI
10.1155/2013/367914