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- Title
Atypical presentation of multicentric Castleman disease in a pediatric patient: pleural and pericardial effusion.
- Authors
Akman, Alkim; Basaran, Ozge; Ozyoruk, Derya; Han, Unsal; Sayli, Tulin; Cakar, Nilgun; Akman, Alkim Oden
- Abstract
<bold>Unlabelled: </bold>Castleman disease (CD) is a rare poorly understood lymphoproliferative disorder. Pediatric onset CD has been reported before. However, most of them have benign unicentric pattern. Multicentric CD (MCD) is quite rare in children. Herein, we report a 13-year-old adolescent boy with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation.<bold>Conclusion: </bold>MCD should be considered in the differential diagnosis of pleural and/or pericardial effusion with unexplained lymph nodes in children. What is Known •Pediatric Castleman disease (CD) most commonly occurs in the unicentric form, which typically is asymptomatic and cured by lymph node excision. •The diagnosis of MCD can be difficult owing to the heterogeneity of presentation and potential for nonspecific multisystem involvement. What is New •A 13-year-old adolescent boy was diagnosed with MCD of the hyaline vascular variant presenting with pleural and pericardial effusion, which is an uncommon presentation. •In a pediatric patient with fever, pleural-pericardial effusion and multiple lymph nodes, MCD should be considered in differantial diagnosis.
- Subjects
CASTLEMAN'S disease; JUVENILE diseases; PERICARDIAL effusion; C-reactive protein; FAMILIAL Mediterranean fever; BLOOD sedimentation; LYMPH node diseases; DIFFERENTIAL diagnosis; ECHOCARDIOGRAPHY; PLEURAL effusions; RADIOGRAPHY; DISEASE complications; DIAGNOSIS
- Publication
European Journal of Pediatrics, 2016, Vol 175, Issue 6, p873
- ISSN
0340-6199
- Publication type
journal article
- DOI
10.1007/s00431-015-2674-6