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- Title
Ovarian cyst torsion in a patient with congenital lipoid adrenal hyperplasia.
- Authors
Hye Young Jin; Jin-Ho Choi; Beom Hee Lee; Gu-Hwan Kim; Hyung Kyung Kim; Han-Wook Yoo; Jin, Hye Young; Choi, Jin-Ho; Lee, Beom Hee; Kim, Gu-Hwan; Kim, Hyung Kyung; Yoo, Han-Wook
- Abstract
Congenital lipoid adrenal hyperplasia (CLAH) is the most severe form of congenital adrenal hyperplasia, characterized by lack of synthesis of all gonadal and adrenal steroid hormones. Ovarian cysts can develop as complications of CLAH. However, the precise mechanism of development and natural history of such cysts in patients with CLAH have not yet been determined. We recently treated a 14-year-old female patient with CLAH and ovarian cyst torsion. As a neonate, she presented with vomiting, skin pigmentation, and electrolyte imbalance. At that time, her serum adrenocorticotropic hormone concentration was elevated, while 17-hydroxypregnenolone level was normal, as were her normal female external genitalia. Mutation analysis showed that she was homozygous for p.Q258X in the StAR gene. She underwent spontaneous puberty and menstruation. At 14 years of age, she received salpingo-oophorectomy because of ovarian cyst torsion presenting as acute pelvic pain. Ovarian cysts are important clinical manifestations in 46,XX patients with CLAH, although onset time and severity can vary depending on individuals. Thus, patients with CLAH should be carefully monitored for ovarian complications to preserve as much ovarian function as possible.
- Subjects
GENETIC disorders; HYPERPLASIA; CYSTS (Pathology); SYMPTOMS; GENETIC load; OVARIECTOMY; ESTROGEN replacement therapy; PROGESTERONE; ADRENAL diseases; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; PHOSPHOPROTEINS; RESEARCH; OVARIAN cysts; EVALUATION research; TREATMENT effectiveness; TORSION abnormality (Anatomy); SALPINGECTOMY; DISEASE complications; DIAGNOSIS; THERAPEUTICS
- Publication
European Journal of Pediatrics, 2011, Vol 170, Issue 4, p535
- ISSN
0340-6199
- Publication type
journal article
- DOI
10.1007/s00431-010-1342-0