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- Title
The Role of Rho GTPases in VEGF Signaling in Cancer Cells.
- Authors
El Baba, Nada; Farran, Mohammad; Khalil, Elie Abi; Jaafar, Leila; Fakhoury, Isabelle; El-Sibai, Mirvat
- Abstract
Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studied. Activation of VEGF signal transduction can be initiated by the molecules' binding to two classes of transmembrane receptors: (1) the VEGF tyrosine kinase receptors (VEGF receptors 1 through 3) and (2) the neuropilins (NRP1 and 2). The involvement of Rho GTPases in modulating VEGFA signaling in both cancer cells and endothelial cells has also been well established. Additionally, different isoforms of Rho GTPases, namely, RhoA, RhoC, and RhoG, have been shown to regulate VEGF expression as well as blood vessel formation. This review article will explore how Rho GTPases modulate VEGF signaling and the consequences of such interaction on cancer progression.
- Subjects
RHO GTPases; VASCULAR endothelial growth factors; PLACENTAL growth factor; CANCER cells; VASCULAR endothelial growth factor receptors; GROWTH factors; PROTEIN-tyrosine kinases
- Publication
Analytical Cellular Pathology: Cellular Oncology, 2020, p1
- ISSN
2210-7177
- Publication type
Article
- DOI
10.1155/2020/2097214