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- Title
Volumetric analysis of the cerebellum with the volBrain method in patients with migraine.
- Authors
Palancı, Özgür; Alioğlu, Zekeriya; Özyaşar, Ali Faruk; Erten, Kübra
- Abstract
Objective: It is known that the cerebellum plays an important role in the processing of pain. In the literature, many structures of the brain have been studied volumetrically by using brain MRI images of migraine patients. Many automated methods have been used to estimate brain volume from MRI images. The functional role of the cerebellum in the pathophysiology of migraine still remains unclear. In this study we aimed to contribute to the pathophysiology of migraine by examining the cerebellum structures of migraine patients. Methods: 19 people (9 women, 10 men) diagnosed with migraine and 14 people (7 women, 7 men) who did not have any neurological disorder were included in the study. The CERES method of volBrain was used to examine the cerebellum volumes of the study groups. With this method, gray matter volumes of each lobe of the cerebellum and cortical thickness of each lobe were obtained. To analyse the study results, we used SPSS 15.0 program and considered p<0.05 as statistically significant. Results: As a result of the analysis, gray matter volumes of the right cerebellum, left cerebellum, Crus I, Crus II, VIIB, VIIIA, VIIIB and cortical thickness of these regions were found to be increased in migraine patients. CrusII, VIIB, VIIIA gray matter volumes of those with a disease duration of 5 years or more are found higher than those with a disease duration of less than 5 years. It was also found that patients who have 10 or more attacks per month have a higher cortical thickness of the CrusII region. The volume increase and cortical thickness in these regions show a statistically significant difference (p<0.05). Conclusion: Crus I and crus II are areas closely connected to the prefrontal and posterior parietal cortical cortex by association fibers. Crus I and crus II are thought to contain cognitive and emotional representations and show an overlapping activity between irritating pain. Further studies are needed to elucielucidate the role of the cerebellum in migraine disease and to investigate its potential role in migraine treatment.
- Subjects
VOLUMETRIC analysis; CEREBELLUM; MIGRAINE; SPREADING cortical depression; GRAY matter (Nerve tissue); SUMATRIPTAN; CEREBELLUM diseases
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2022, Vol 16, pS10
- ISSN
1307-8798
- Publication type
Abstract