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- Title
Volumetric changes within hippocampal formation subfields in Alzheimer's disease continuum.
- Authors
Han, Emre; Evin, Gözde Krnlateş; Kurt, Elif; Yıldız, Çiğdem Ulafloğlu; Acar, Burak; Demiralp, Tamer; Gürvit, İ. Hakan
- Abstract
Objective: Progressive degeneration in Alzheimer's disease continuum (ADC) starts from transentorhinal cortex and progresses within hippocampal formation (HF) structures. The investigation of the neurodegeneration spread pattern through the HF subfields in this continuum is critical for the early detection of AD. In this study, we aimed to track the volumetric changes of the HF subfields along the ADC by using magnetic resonance imaging (MRI). Methods: Structural MRI data of 15 patients diagnosed with Alzheimer's disease dementia (ADD), 15 amnestic mild cognitive impairment (MCI) and 15 subjective cognitive impairment (SCI) were used, and they were matched in terms of age, education and gender. HF is individually subdivided into dentate gyrus (DG), subiculum (SUB), CA1 and CA3, and volume values were obtained using FreeSurfer software (http://surfer. nmr.mgh.harvard.edu/). ANCOVA analysis with intracranial volume as covariate was performed to evaluate the differences between the groups. Bonferroni correction with p<0.005 was applied on F-test results and with p<0.0017 for t-tests between pairs of groups. Results: As a result, statistically significant volume reductions were detected among the three groups from SCI towards ADD in bilateral CA1, DG and SUB. In ADD, DG, SUB and CA1 volumes were less compared to SCI. Additionally, the volumes of DG in left hemisphere, SUB and DG in right hemisphere were statistically lower in ADD compared to MCI. Conclusion: In the volumetric studies conducted with the ADC, volume loss was reported in the early stages, especially in CA1 and SUB, and with a lesser degree in DG. While the results of our study are generally consistent with the literature, they additionally point to importance of the progressive volume loss in DG. This pattern of volume decrease is compatible with tau transsynaptic spread in the intrinsic hippocampal circuit.
- Subjects
ALZHEIMER'S disease; AMNESTIC mild cognitive impairment; HIPPOCAMPUS (Brain); DENTATE gyrus; MAGNETIC resonance imaging
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2020, Vol 14, pS105
- ISSN
1307-8798
- Publication type
Article