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- Title
LncRNA SOX2OT rs9839776 Polymorphism Reduces Sepsis Susceptibility in Southern Chinese Children.
- Authors
Wu, Zhiyuan; Yu, Yongqin; Fu, Lanyan; Mai, Hanran; Huang, Li; Che, Di; Tao, Jianping; Gu, Xiaoqiong
- Abstract
Background: Sepsis in children is one of the main causes of death in pediatric intensive care units (PICUs); however, the pathogenesis of sepsis is not fully clear. Previous studies revealed that many genetic variations were related to sepsis susceptibility. A long non-coding RNA SOX2 overlapping transcript (SOX2OT) may play a role in mitochondrial homeostasis and antioxidative activity, but the relationship between the lncRNA SOX2OT polymorphism and sepsis susceptibility has not been reported. Methods: In this study, 474 pediatric sepsis patients and 678 healthy controls were recruited from southern China. After genotyping, the strength of the associations was evaluated through odds ratios (ORs) and 95% confidence intervals (CIs). Results: The SOX2OT rs9839776 T allele was associated with decreased susceptibility to sepsis in southern Chinese children (TT/CT vs CC adjusted OR = 0.778, 95% CI = 0.610– 0.992; P = 0.0431). Moreover, the difference in susceptibility was greater in children of age > 60 months (adjusted OR = 0.458, 95% CI = 0.234– 0.896; P = 0.0225), survivors (adjusted OR = 0.758, 95% CI = 0.585– 0.972; P = 0.0358), males (adjusted OR = 0.655, 95% CI = 0.479– 0.894; P = 0.0077) and the sepsis subgroup (adjusted OR = 0.548, 95% CI = 0.343– 0.876; P = 0.0120). Conclusion: The rs9839776 T allele may contribute to decreased sepsis risk in Chinese children. Future studies with a larger sample size are needed to verify these results.
- Subjects
CHINA; CHINESE people; SEPSIS; PEDIATRIC intensive care; LINCRNA; INTENSIVE care units
- Publication
Journal of Inflammation Research, 2020, Vol 13, p1095
- ISSN
1178-7031
- Publication type
Article
- DOI
10.2147/JIR.S281760