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- Title
Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier.
- Authors
Baquerizo, Katherine; Amini, Sadegh; Keri, Jonette E.; Badiavas, Evangelos V.; Elgart, George W.
- Abstract
We report the first documented case of an atypical form of transient reactive papulotranslucent acrokeratoderma (TRPA) in a patient heterozygous for the Δ F508 CFTR(cystic fibrosis transmembrane conductance regulator) mutation. TRPA represents a condition that classically presents with translucent to white plaques that become evident after water exposure. An atypical form with persistent lesions has also been described. Our patient is a 16-year-old girl with small, white papules coalescing into pebbly plaques on the palms. This condition is exacerbated after 5-10 min of water exposure and is associated with discomfort. The skin biopsy showed expanded stratum corneum, orthohyperkeratosis and dilation of eccrine ducts consisting with TRPA. A cystic fibrosis carrier state, barrier function defect, hyperhidrosis and the intake of cyclooxygenase inhibitors may have been pathogenic factors in our patient.
- Subjects
HAND diseases; SKIN biopsy; CYSTIC fibrosis transmembrane conductance regulator; CYCLOOXYGENASE inhibitors
- Publication
Journal of Cutaneous Pathology, 2013, Vol 40, Issue 4, p413
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.12087