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- Title
A Computational Approach towards the Development of Newer Anticancer Agents.
- Authors
Sheikh, Javed I.; Juneja, H. D.; Ingle, V. N.
- Abstract
In silico molecular docking analyses of the novel 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-aryl-propane-1, 3-diones were performed in the active sites of enzyme cytochrome P450 reductase to obtain new anticancer agents computationally. 1-(2', 4'-dihydroxy-5'-chlorophenyl)-3-(4"-methoxyphenyl)- propane-1, 3-dione (3f) was found to have maximum affinity for the active sites of enzyme.
- Subjects
ANTINEOPLASTIC agents; CYTOCHROMES; ENZYMES; DIBENZOYLMETHANE; CARCINOGENESIS; MICROSOMES; GENETIC algorithms; PROPANE; KETONES
- Publication
E-Journal of Chemistry, 2010, Vol 7, Issue 1, p21
- ISSN
0973-4945
- Publication type
Article
- DOI
10.1155/2010/582710