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- Title
Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells.
- Authors
Shin, Dong-Mi; Choi, Kyeong-Mi; Lee, Youn-Sun; Kim, Wonkyun; Shin, Kyong-Oh; Oh, Seikwan; Jung, Jae-Chul; Lee, Mi; Lee, Yong-Moon; Hong, Jin; Yun, Yeo-Pyo; Yoo, Hwan-Soo
- Abstract
Echinacea purpurea has been shown to have anti-diabetic activities; for example, it activates peroxisome proliferator-activated receptor γ (PPARγ) and increases insulin-stimulated glucose uptake. Adipogenesis has been used to study the insulin signaling pathway and to screen anti-diabetic compounds. The present study was conducted to investigate the effects of an ethanol extract of E. purpurea (EEEP) and its constituents on the insulin-induced adipocyte differentiation of 3T3-L1 preadipocytes. When adipocyte differentiation was induced with insulin plus 3-isobutyl-1-methylxanthine and dexamethasone, the accumulation of lipid droplets and the cellular triglyceride content were significantly increased by EEEP. The expressions of PPARγ and C/EBPα in adipocytes treated with EEEP were gradually increased as compared with control cells. Fat accumulation and triglyceride content of adipocytes treated with dodeca-2( E),4( E)-dienoic acid isobutylamide were significantly increased as compared with control cells. The expressions of PPARγ and C/EBPα in adipocytes treated with dodeca-2( E),4( E)-dienoic acid isobutylamide were significantly higher than in control cells. These results suggest EEEP promotes the adipogenesis that is partially induced by insulin and that dodeca-2( E),4( E)-dienoic acid isobutylamide appears to be responsible for EEEP-enhanced adipocyte differentiation.
- Publication
Archives of Pharmacal Research, 2014, Vol 37, Issue 6, p803
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/s12272-013-0251-y