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- Title
Quasi-steadiness approximation for the two-compartment solute kinetic model.
- Authors
Koike, Jun; Ujiie, Kazutomo; Owada, Akira; Shiigai, Tatsuo; Matsui, Noriaki; Nonoguchi, Hiroshi; Tomita, Kimio; Marumo, Fumiaki
- Abstract
Quasi-steadiness approximation for the two-compartment solute kinectic model. We analytically solved the equation of the variable volume two-compartment solute kinetic model (TCSKM). From the solution we constructed an expression of weekly concentration profiles developing in the patient's body by routine hemodialyses. Obtained formulas can be used to calculate Ki/V; solute index (SRI), the generation rate (G) per unit distribution volume (V) and a mass transfer coefficient (MTC) between the two compartments. To estimate these parameters the formula only need three-point data during a dialysis that is pre one-hour and post-dialysis solute concentrations instead of four that would otherwise be needed A 48 hour data point is not required . The weekly concentration profiles can be easily calculated by the formulas. As example of clinical applications we calculated. Kt/V2, G/V and SRl of urea Cr and uric acid using plasma data of 121 hemodialyzed patients then the results were compared with the single-compartment solute kinetic model (SCSKM). The obtained mean MTC/V values that is 1.08 (Uhr) for area 0.53 (1/hr) for Cr and 1.11 (1/hr) for uric acid were consistent with the previous works .SCSKM overestimated the mean G/V by 7.1% 15.9% and 10% and the mean SRl by 6.7% 18.6% and 10.0% for urea. Cr and urea acid respectively. The solute distribution volume ratio of TCSKM to SCSKM (V)SCSKMK, depend on the value of MTC/V and the hemodialysis duration. Using pedometer, we measured the total number of steps the patients took during a week. We found that the total number of steps in a week was significantly correlated with the Cr generation rate (<em>r</em> = 0.825, <em>P</em> < 0.03) but that it was not significantly correlated with the other generation rates (<em>r</em>=0.204, <em>P</em> < 0.09) for urea and <em>i</em> = 0.209, <em>P</em> >0.08 for urea acid ). These data suggest that the Cr generation rate is related to the patient's physical activity. We concluded that the formulas can estimate can estimate an adequate dialysis prescription for the hemodialyzed patient.
- Subjects
HEMODIALYSIS patients; DYNAMICS; CREATININE; MASS transfer; THERMODYNAMICS; DIALYSIS (Chemistry)
- Publication
Kidney International, 1997, Vol 52, Issue 3, p821
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1997.400