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- Title
Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats.
- Authors
Flemmig, T. F.; E.Milián; Kopp, C.; Karch, H.; Klaiber, B.
- Abstract
48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test), subgingival plaque and swab snicks from tongue, tonsils and buccal mucous were taken at baseline. 10 days and 3. 6. 9. and 12 months. A. actinomycetemcuntitans was detected in the oral cavity i.e. subgingival plaque and/or mucous membranes, less frequently in test patients compared to controls at 9 and 12 months (p<0.01). whereas, the intraoral detection frequency of P. gingivalis was significantly reduced only 10 days following therapy (p<0.001). At any time after therapy. A. actinomycetemcomitans was not detected intraorally in 5 of 10 (50%) test and 1I of 13 (8%) control patients harboring this pathogen at baseline: P. gingivaIis was not detected in only 1 of 18 (6%) test and none of the 17 control patients harboring this pathogen at baseline. Although the data indicated that the assessed antimicrobial therapy may suppress A. actinomycetemcomitans from the entire oral cavity below detectable levels over a minimum of 12 months, P. gingivalis persisted or reoccurred.
- Subjects
PERIODONTITIS; ACTINOBACILLUS; PORPHYROMONAS gingivalis; ANTIBIOTICS; METRONIDAZOLE; AMOXICILLIN
- Publication
Journal of Clinical Periodontology, 1998, Vol 25, Issue 1, p1
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/j.1600-051X.1998.tb02356.x