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- Title
IgA nephropathy associated with dental nickel alloy sensitization.
- Authors
Strauss, Franklin G.; Eggleston, David W.; Strauss, F G; Eggleston, D W
- Abstract
We report a patient with documented IgA nephropathy in whom microscopic hematuria, proteinuria, and hypertension first occurred after placement of nickel alloy base dental crowns. Progressive proteinuria culminating in nephrotic-range proteinuria occurred parallel to increased nickel placement and dramatically resolved following nickel alloy removal. That immunologic alterations occur as a result of nickel exposure has already been suggested by the common occurrence of nickel contact dermatitis, often exacerbated by intraoral nickel placement, increased carcinogenesis in nickel refinery workers, and animal models of nickel-associated carcinogenesis. Our patient may represent an example of nickel-induced sensitization and associated IgA glomerulopathy. Further study of patients with immune-mediated glomerulopathy with attention to dental nickel exposure appears indicated.
- Subjects
DENTAL metallurgy; CONTACT dermatitis; DENTAL crowns; DRUG allergy; ELECTRON microscopy; GLOMERULONEPHRITIS; NICKEL; DISEASE complications
- Publication
American Journal of Nephrology, 1985, Vol 5, Issue 5, p395
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000166973