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- Title
KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas.
- Authors
Kunder, Christian A.; Roncador, Giovanna; Advani, Ranjana H.; Gualco, Gabriela; Bacchi, Carlos E.; Sabile, Jean M.; Lossos, Izidore S.; Kexin Nie; Tibshirani, Robert John; Green, Michael R.; Alizadeh, Ash A.; Natkunam, Yasodha
- Abstract
Objectives: KLHL6 is a recently described BTB-Kelch protein with selective expression in lymphoid tissues and is most strongly expressed in germinal center B cells. Methods: Using gene expression profiling as well as immunohistochemistry with an anti-KLHL6 monoclonal antibody, we have characterized the expression of this molecule in normal and neoplastic tissues. Protein expression was evaluated in 1,058 hematopoietic neoplasms. Results: Consistent with its discovery as a germinal center marker, KLHL6 was positive mainly in B-cell neoplasms of germinal center derivation, including 95% of follicular lymphomas (106/112). B-cell lymphomas of non-germinal center derivation were generally negative (0/33 chronic lymphocytic leukemias/small lymphocytic lymphomas, 3/49 marginal zone lymphomas, and 2/66 mantle cell lymphomas). Conclusions: In addition to other germinal center markers, including BCL6, CD10, HGAL, and LMO2, KLHL6 immunohistochemistry may prove a useful adjunct in the diagnosis and future classification of B-cell lymphomas.
- Subjects
BCL-2 proteins; MONOCLONAL antibodies; LYMPHOID tissue
- Publication
American Journal of Clinical Pathology, 2017, Vol 148, Issue 6, p465
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1093/AJCP/AQX099