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- Title
Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin.
- Authors
Steinhoff, Martin; Neisus, Ulrich; Ikoma, Akihiko; Fartasch, Manige; Heyer, Gisella; Skov, Per S.; Luger, Thomas A.; Schmelz, Martin
- Abstract
Examines whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. Use of local antihistamines to abolish mast cell degranulation; Overview of codeine-induced mediator release; Assessment of vascular and neuronal responses to injection of the endogenous ligand; Intracutaneous injection of the endogenous PAR-2 agonist.
- Subjects
PROTEINASES; ITCHING; SKIN; ANTIHISTAMINES; CODEINE; NEURONS
- Publication
Journal of Neuroscience, 2003, Vol 23, Issue 15, p6176
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.23-15-06176.2003