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- Title
Silkworms can be used as an animal model to screen and evaluate gouty therapeutic drugs.
- Authors
Xiaoli Zhang; Renyu Xue; Guangli Cao; Zhonghua Pan; Xiaojian Zheng; Chengliang Gong
- Abstract
The article focuses on a study which examined effects of gouty therapeutic drugs on lowering the content of uric acid and inhibiting activity of xanthine oxidase in silkworm model Bombyx mori L. of hyperuricemia and gout. The study described the activity of xanthine oxidase of silkworm treated with allopurinol. It showed that the effectiveness of oral administration of gouty therapeutic drugs to 5th instar silkworms is the same with that of humans.
- Subjects
PHARMACODYNAMICS; SILKWORMS; XANTHINE oxidase; URIC acid; ALLOPURINOL
- Publication
Journal of Insect Science, 2012, Vol 12, p1
- ISSN
1536-2442
- Publication type
Article
- DOI
10.1673/031.012.0401