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- Title
Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis.
- Authors
Kardys, A.; Weinstock‐Guttman, B.; Dillon, M.; Masud, M. W.; Weinstock, N.; Mahfooz, N.; Lang, J. K.; Weinstock, A.; Lincoff, N.; Zivadinov, R.; Ramanathan, M.
- Abstract
Background and purpose To evaluate the associations between retinal nerve fiber layer ( RNFL) thickness and lipid profiles in multiple sclerosis ( MS). Methods This study enrolled 136 patients with MS ( n = 272 eyes; 108 females, 28 males, mean age: 46.7 ± 8.9 years); 45% had a history of optic neuritis (ON). Subjects received optical coherence tomography ( OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts. A subset of 88 patients received pattern reversal visual-evoked potential ( PRVEP) testing. Lipid profiles consisting of serum high-density lipoprotein ( HDL) cholesterol, low-density lipoprotein ( LDL) cholesterol and total cholesterol (TC) levels were obtained within ± 6 months of OCT. Regression analyses were used to assess the associations between RNFL thickness and lipid profile variables. Results Low RNFL thickness ( P = 0.008) and higher PRVEP latency ( P = 0.017) were associated with high LDL cholesterol > 100 mg/dl status. Low RNFL thickness ( P = 0.008) and higher PRVEP latency ( P = 0.043) were associated with high HDL cholesterol levels. Low RNFL thickness was also associated with HDL cholesterol > 60 mg/dl status ( P = 0.001) and with TC > 200 mg/dl status ( P = 0.015). The probability of average RNFL thickness in the lowest tertile (≤ 33rd percentile) was associated with interactions between TC > 200 mg/dl status ( P = 0.001, odds ratio = 7.5, 95% confidence interval = 2.7-21) with affected/unaffected by ON status. Conclusions High cholesterol adversely affects RNFL thickness in patients with MS with ON.
- Subjects
NERVE fibers; PHYSIOLOGICAL effects of cholesterol; MULTIPLE sclerosis; OPTIC neuritis; OPTICAL coherence tomography; VISUAL acuity; VISUAL evoked potentials; PATIENTS
- Publication
European Journal of Neurology, 2013, Vol 20, Issue 9, p1264
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/ene.12162