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- Title
Curcumin Attenuates Gastric Cancer Induced by N-Methyl-N-Nitrosourea and Saturated Sodium Chloride in Rats.
- Authors
Kawiya Sintara; Duangporn Thong-Ngam; Suthiluk Patumraj; Naruemon Klaikeaw
- Abstract
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU+ s-NaCl, MNU+ s-NaCl supplemented with 200 mg/kg curcumin daily for the first 3 weeks (MNU+ s-NaCl +C3W), and MNU+ s-NaCl supplemented with curcumin for 20 weeks (MNU+ s-NaCl + C20W). To induce stomach cancer, rats except for CO and CC were orally treated with 100 mg/kg MNU on day 0 and 14, and s-NaCl twice-a-week for the first 3 weeks. The experiment was finished and rats were sacrificed at the end of 20 weeks. Cancers were found in forestomachs of all rats inMNU+ s- NaCl. The expressions of phosphorylated inhibitor kappaB alpha (phospho-IκBα ), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and cyclin D1 significantly increased in MNU+ s-NaCl compared with CO. Curcumin treatments for 3 and 20 weeks reduced the cancer incidence resulting in a decrease of phospho-IκBα expression in benign tumor-bearing rats compared with MNU+ s-NaCl. Curcumin treatment for 20 weeks also decreased 8-OHdG expression in benign tumor-bearing rats compared with MNU+ s- NaCl. Curcumin can attenuate cancer via a reduction of phospho-IκBα and 8-OHdG expressions, which may play a promising role in gastric carcinogenesis.
- Subjects
ANALYSIS of variance; ANIMAL experimentation; IMMUNOHISTOCHEMISTRY; RATS; RESEARCH funding; SALT; STATISTICS; STOMACH tumors; UREA; WESTERN immunoblotting; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; CURCUMIN
- Publication
Journal of Biomedicine & Biotechnology, 2012, Vol 2012, p1
- ISSN
1110-7243
- Publication type
Article
- DOI
10.1155/2012/915380