We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Transcription as a force partitioning the eukaryotic genome.
- Authors
Zirkel, Anne; Papantonis, Argyris
- Abstract
Eukaryotic genomes - until recently dealt with as if they were a cohort of linear DNA molecules - are perplexed three-dimensional structures, the exact conformation of which profoundly affects genome function. Recent advances in molecular biology and DNA sequencing technologies have led to a new understanding of the folding of chromatin in the nucleus. Changes in chromatin structure underlie deployment of new gene expression programs during development, differentiation, or disease. In this review, we revisit data pointing to, arguably, the major force that shapes genomes: transcription of DNA into RNA.
- Subjects
EUKARYOTIC genomes; NUCLEOTIDE sequencing; RNA; GENE expression; CELL differentiation
- Publication
Biological Chemistry, 2014, Vol 395, Issue 11, p1301
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2014-0196