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- Title
A scoring system based on the expression of six surface molecules allows the identification of three prognostic risk groups in B-cell chronic lymphocytic leukemia.
- Authors
Zucchetto, Antonella; Bomben, Riccardo; Dal Bo, Michele; Sonego, Paolo; Nanni, Paola; Rupolo, Maurizio; Bulian, Pietro; Dal Maso, Luigino; Del Poeta, Giovanni; Del Principe, Maria Ilaria; Degan, Massimo; Gattei, Valter
- Abstract
We have previously identified 12 surface antigens whose differential expression represented the signature of B-cell chronic lymphocytic leukemia (B-CLL) subsets with different prognosis. In the present study, expression data for these antigens, as determined in 137 B-CLL cases, all with survivals, were utilized to devise a comprehensive immunophenotypic scoring system of prognostic relevance for B-CLL patients. In particular, univariate z score was employed to identify the markers with greater prognostic impact, while maximally selected log-rank statistics were chosen to define the optimal cut-off points capable to split patients into two groups with different survivals. A weighted immunophenotypic scoring system was developed by integrating results from these analyses. Six antigens were selected: three positive prognosticators (CD62L, CD54, CD49c) and three negative prognosticators (CD49d, CD38, CD79b), with cut-off values ranging from 30% to 50% of positive cells. By weighing the expression of each marker according to its statistical power, a complete scoring system, with point values comprised between 0 (complete absence of phenotypic conditions associated with good prognosis) and 9 (all the phenotypic conditions associated with good prognosis fulfilled), allowed to split the whole set of B-CLL patients, into three distinctive prognostic groups (P = 4.78 × 10-11) with high- (score 0–3), intermediate- (score 4–6), and low- (score 7–9) risk of death. The three risk groups showed different distribution of cases as for Rai's stages, IgVH mutations, and ZAP-70 expression. The proposed immunophenotypic scoring system may be an additional useful tool in routine diagnostic/prognostic procedures for B-CLL. J. Cell. Physiol. 207: 354–363, 2006. © 2005 Wiley-Liss, Inc.
- Subjects
LYMPHOCYTIC leukemia; CHRONIC diseases; B cells; PROGNOSIS; IMMUNOPHENOTYPING; PATIENTS
- Publication
Journal of Cellular Physiology, 2006, Vol 207, Issue 2, p354
- ISSN
0021-9541
- Publication type
Article
- DOI
10.1002/jcp.20570