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- Title
Mitogen-activated protein kinases and asthma.
- Authors
Girolamo Pelaia; Giovanni Cuda; Alessandro Vatrella; Luca Gallelli; Michele Caraglia; Monica Marra; Alberto Abbruzzese; Mario Caputi; Rosario Maselli; Francesco S. Costanzo; Serafino A. Marsico
- Abstract
Mitogen-activated protein kinases (MAPKs) are evolutionary conserved enzymes which play a key role in signal transduction mediated by cytokines, growth factors, neurotransmitters and various types of environmental stresses. In the airways, these extracellular stimuli elicit complex inflammatory and structural changes leading to the typical features of asthma including T cell activation, eosinophil and mast cell infiltration, as well as bronchial hyperresponsiveness and airway remodelling. Because MAPKs represent an important point of convergence for several different signalling pathways, they affect multiple aspects of normal airway function and also significantly contribute to asthma pathophysiology. Therefore, this review focuses on the crucial involvement of MAPKs in asthma pathogenesis, thus also discussing their emerging role as molecular targets for anti-asthma drugs. 2004 Wiley-Liss, Inc.
- Subjects
ANTIASTHMATIC agents; ASTHMA; ASTHMATICS; PHOSPHOTRANSFERASES
- Publication
Journal of Cellular Physiology, 2005, Vol 202, Issue 3, p642
- ISSN
0021-9541
- Publication type
Article
- DOI
10.1002/jcp.20169