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- Title
Synthesis of pyrazolo[3,4-b]pyridine and pyrido[2′,3′:3,4]pyrazolo [1,5-a]pyrimidine derivatives.
- Authors
El-Enany, Mervat M.; El-Meligie, Salwa E. M.; Abdou, Nadia A.; El-Nassan, Hala B.
- Abstract
The synthesis of two series of 1-phenyl and 1H-pyrazolo[3,4-b]pyridine is described. Thus, reacting 5-amino-1-phenylpyrazole with chalcone analogues gave 4,6-diarylpyrazolo[3,4-b]pyridine derivatives. While, reacting the same starting material with benzylidene derivatives of ethyl cyanoacetate and malononitrile resulted in 4-oxo and 4-aminopyrazolo[3,4-b]pyridine derivatives, respectively. The synthesis of 3-amino-4,6-diarylpyrazolo[3,4-b]pyridines starting from pyridine was also described. Thus, chlorination of 4,6-diarylpyridone derivatives and their subsequent cyclisation with hydrazine hydrate afforded 3-amino-4,6-diarylpyrazolo[3,4-b]pyridines. Reaction of the latter compounds with acetylacetone, ethyl ethoxymethylenecyanoacetate and chalcone analogue gave the tricyclic pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines. The structures of the products were confirmed by spectral data.
- Publication
Journal of Chemical Research, 2010, Vol 34, Issue 8, p470
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/030823410X12811125049438