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- Title
Myocardial perfusion imaging and risk classification for coronary heart disease in diabetic patients. The IDIS study: a prospective, multicentre trial.
- Authors
Acampa, Wanda; Petretta, Mario; Evangelista, Laura; Daniele, Stefania; Xhoxhi, Evgjeni; Rimini, Maria; Cittanti, Corrado; Marranzano, Filippo; Spadafora, Marco; Baldari, Sergio; Mansi, Luigi; Cuocolo, Alberto
- Abstract
Purpose: To determine whether stress-rest myocardial perfusion single-photon emission (MPS) computed tomography improves coronary heart disease (CHD) risk classification in diabetic patients. Methods: In 822 consecutive diabetic patients, risk estimates for a CHD event were categorized as 0% to <3%, 3% to <5%, and ≥5% per year using Cox proportional hazards models. Model 1 used traditional CHD risk factors and electrocardiography (ECG) stress test data and model 2 used these variables plus MPS imaging data. We calculated the net reclassification improvement (NRI) and compared the distribution of risk using model 2 vs. model 1. CHD death, myocardial infarction and unstable angina requiring coronary revascularization were the outcome measures. Results: During follow-up (58 ± 11 months), 148 events occurred. Model 2 improved risk prediction compared to model 1 (NRI 0.25, 95% confidence interval, CI, 0.15-0.34; p < 0.001). Overall, 301 patients were reclassified to a higher risk category, with an event rate of 28%, and 26 to a lower risk category, with an event rate of 15%. Among patients at 3% to <5% risk, 53% were reclassified at higher risk and 25% at lower risk (NRI 0.42, 95% CI 0.07-0.76; p < 0.05). The cost per NRI was $880.80 for MPS imaging as compared to an outpatient visit with an ECG stress test. Conclusion: The addition of MPS imaging data to a prediction model based on traditional risk factors and ECG stress test data significantly improved CHD risk classification in patients with diabetes.
- Subjects
MECHANICAL hearts; CORONARY disease; PEOPLE with diabetes; TOMOGRAPHY; ELECTROCARDIOGRAPHY; MYOCARDIAL infarction
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2012, Vol 39, Issue 3, p387
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-011-1983-x