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- Title
Pharmacological and Functional Characterization of Endothelin Receptors in Bovine Trabecular Meshwork and Ciliary Muscle.
- Authors
Choritz, Lars; Rosenthal, Rita; Fromm, Michael; Foerster, Michael H.; Thieme, Hagen
- Abstract
To clarify the potential role of endothelin-1 (ET-1) in the pathogenesis of glaucoma, the endothelin receptors expressed in bovine trabecular meshwork (TM) and ciliary muscle (CM) were identified. TM and CM strips were subjected to ET-1 as well as to specific endothelin receptor antagonists. In both tissues BQ123, a specific ET-A receptor antagonist, substantially inhibited ET-1-induced contraction. BQ788, a specific ET-B receptor antagonist, showed only moderate effects. Both ET receptor types were detected in bovine TM and CM using Western blot analysis. ET-1 produced an increase in intracellular calcium in cultured TM cells. This effect was inhibited by BQ123, but not by BQ788. Thus, although both receptors are present, the ET-A receptor appears to play the predominant role in mediating contraction in both the TM and CM, while the ET-B receptor seems to contribute little to the overall ET-1 effect. Copyright © 2005 S. Karger AG, Basel
- Publication
Ophthalmic Research, 2005, Vol 37, Issue 4, p179
- ISSN
0030-3747
- Publication type
Article
- DOI
10.1159/000086471