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- Title
PD-1<sup>hi</sup> CD8<sup>+</sup> resident memory T cells balance immunity and fibrotic sequelae.
- Authors
Zheng Wang; Shaohua Wang; Goplen, Nick P.; Chaofan Li; In Su Cheon; Qigang Dai; Su Huang; Jinjun Shan; Chaoyu Ma; Zhenqing Ye; Min Xiang; Limper, Andrew H.; Porquera, Eva-Carmona; Kohlmeier, Jacob E.; Kaplan, Mark H.; Nu Zhang; Johnson, Aaron J.; Vassallo, Robert; Jie Sun
- Abstract
CD8+ tissue-resident memory T (TRM) cells provide frontline immunity in mucosal tissues. The mechanisms regulating CD8+ TRM maintenance, heterogeneity, and protective and pathological functions are largely elusive. Here, we identify a population of CD8+ TRM cells that is maintained by major histocompatibility complex class I (MHC-I) signaling, and CD80 and CD86 costimulation after acute influenza infection. These TRM cells have both exhaustedlike phenotypes and memory features and provide heterologous immunity against secondary infection. PD-L1 blockade after the resolution of primary infection promotes the rejuvenation of these exhausted-like TRM cells, restoring protective immunity at the cost of promoting postinfection inflammatory and fibrotic sequelae. Thus, PD-1 serves to limit the pathogenic capacity of exhausted-like TRM cells at the memory phase. Our data indicate that TRM cell exhaustion is the result of a tissue-specific cellular adaptation that balances fibrotic sequelae with protective immunity
- Publication
Science Immunology, 2019, Vol 4, Issue 36, p1
- ISSN
2470-9468
- Publication type
Article
- DOI
10.1126/sciimmunol.aaw1217