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- Title
Hepatitis C virus infection could be a risk factor for adult‐onset vitiligo in Egyptian patients: A cross‐sectional study.
- Authors
Fawzy, Manal M.; Hammad, Noha M.; Sharaf, Ahmed L.; Khattab, Fathia
- Abstract
Background: Vitiligo is a common skin disorder resulting from the destruction of melanocytes. Hepatitis C virus (HCV) infection has been linked to a variety of extrahepatic manifestations, including skin diseases. Aim: To measure the prevalence of HCV‐seroreactivity among vitiligo patients. Methods: This cross‐sectional study included 108 vitiligo patients. Serum anti‐HCV antibodies were detected by chemiluminescence immunoassay. Results: Eighteen patients (16.7%) out of 108 were HCV‐reactive; all of them had adult‐onset vitiligo. They represented approximately 34.6% of the total patients with adult‐onset vitiligo (52 patients). On the contrary, all patients with childhood‐onset vitiligo were HCV‐non‐reactive. Moreover, adult‐onset vitiligo was significantly associated with HCV‐seroreactivity (p <.001). Also, there was a significant difference between HCV‐reactive and HCV‐non‐reactive vitiligo patients regarding the age of patients and their ages at the onset of vitiligo (p <.001). Conclusions: HCV may be the triggering factor for adult‐onset vitiligo, particularly in regions with a high prevalence of HCV. Therefore, patients with adult‐onset vitiligo, rather than childhood‐onset disease, should be screened for associated HCV infection in HCV‐endemic regions.
- Subjects
HEPATITIS C; VITILIGO; EGYPTIANS; CHEMILUMINESCENCE immunoassay; HEPATITIS C virus; CROSS-sectional method
- Publication
Journal of Cosmetic Dermatology, 2022, Vol 21, Issue 10, p4983
- ISSN
1473-2130
- Publication type
Article
- DOI
10.1111/jocd.14946