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- Title
Observational Study on Antibody Response to COVID-19 Vaccines in PAtients with Gastro-Entero-PanCreatic Cancers and NeuroendocrIne NeoplAsms on Systemic TreatmEnts (VACCINATE).
- Authors
Laffi, Alice; Gervaso, Lorenzo; D'Ecclesiis, Oriana; Gandini, Sara; Riva, Agostino; Passerini, Rita; Spada, Francesca; Pellicori, Stefania; Rubino, Manila; Cella, Chiara Alessandra; Ravenda, Paola Simona; Zampino, Maria Giulia; Fazio, Nicola
- Abstract
The coronavirus disease-19 (COVID-19) pandemic dramatically impacted oncological patients' care. Since the introduction of vaccines and the demonstration of their benefit on frail patients, COVID-19 vaccinations were indicated to also be beneficial to oncological population. However, data about the impact of anticancer-treatments and the timing between vaccinations and systemic therapy delivery were not available. We aimed to evaluate potential factors influencing the outcome of the COVID-19 vaccination in cancer patients. We prospectively collected data of patients undergoing the COVID-19 vaccination with gastro-entero-pancreatic and neuroendocrine neoplasms, treated at our institute, between 03/2021 and 12/2021. We enrolled 46 patients, 63.1% males; at the time of data collection, 86.9% had received two-doses of Pfizer-BioNTech and the rest had received the Moderna vaccine. All patients obtained a subsequent immune-response. Chemotherapy seems to determinate a significantly lower antibody response after vaccination compared to the other anti-cancer agents (p = 0.004). No significant effect on immune-response was reported for both vaccinations performed ≤7 vs. >7 days from the last systemic treatment (p = 0.77) and lymphocytes count (p = 0.11). The findings suggest that the optimal timing for COVID-19 vaccination and lymphocytes count are not the issue, but rather that the quality of the subset of lymphocytes before the vaccination determine the efficacy level of immune-response in this population.
- Subjects
COVID-19 pandemic; COVID-19; NEUROENDOCRINE tumors; VACCINE effectiveness; ANTIBODY formation; NEUTRALIZATION tests; LYMPHOCYTE count
- Publication
Biomedicines, 2023, Vol 11, Issue 2, p336
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11020336