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- Title
(Dis)similarities between the Decidual and Tumor Microenvironment.
- Authors
Krstic, Jelena; Deutsch, Alexander; Fuchs, Julia; Gauster, Martin; Gorsek Sparovec, Tina; Hiden, Ursula; Krappinger, Julian Christopher; Moser, Gerit; Pansy, Katrin; Szmyra, Marta; Gold, Daniela; Feichtinger, Julia; Huppertz, Berthold
- Abstract
Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system. Similarly, tumor cells can invade surrounding tissues and escape the immune system. Importantly, both trophoblast and tumor cells are supported by an abetting microenvironment, which influences invasion, angiogenesis, and immune tolerance/evasion, among others. However, in contrast to tumor cells, the metabolic, proliferative, migrative, and invasive states of trophoblast cells are under tight regulatory control. In this review, we provide an overview of similarities and dissimilarities in regulatory processes that drive trophoblast and tumor cell fate, particularly focusing on the role of the abetting microenvironments.
- Subjects
TUMOR microenvironment; TROPHOBLAST; IMMUNOLOGICAL tolerance; IMMUNE system
- Publication
Biomedicines, 2022, Vol 10, Issue 5, p1065
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10051065